CASE REPORTS Malakoplakia of colon
نویسنده
چکیده
Malakoplakia, first described by Michaelis and Gutmann in 1902 [1], occurs mainly in the genitourinary tract (60% of cases), and less frequently in the gastrointestinal tract (10% of cases) [2]. Although the pathogenesis of malakoplakia is not completely understood, the disease may be considered the result of an impairment of the mononuclear phagocyte and immunoregulatory effector system [3]. The foci of malakoplakia characteristically consist of proliferation of histiocytes with the typical cytoplasmic inclusions known as Michaelis-Gutmann bodies that probably correspond to lysosomes. This rare condition may be associated with inflammatory and infectious diseases, immunosuppressive therapy such as steroids and with tumours such as colorectal carcinoma [4].
منابع مشابه
MALAKOPLAKIA OF THE COLON: A CASE REPORT AND LITERATURE REVIEW
Malakoplakia is a rare disease with undefined etiology that has been almost exclusively reported in urology and pathology journals. We are presenting a case of colonic malakoplakia in an I8-year old young man who was referred to us with a four-year history of intermittent rectorrhagia. The pathological examination of the endoscopically resected specimen revealed pathognomonic features of ma...
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Malakoplakia is a rare granulomatous disease of the genitourinary system. Gastrointestinal tract is the second most common site of involvement. It usually mimics a malignancy but its association with adenocarcinoma has been rarely reported. A 59-year-old male patient with the history of weight loss and rectal bleeding for two months prior to administration was referred ...
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INTRODUCTION Malakoplakia is chronic granulomatous disorder resulting from an abnormal immunological response resulting in accumulation of histiocytes [1].It normally involves the urinary bladder, colon, skin etc. But bone is rarely involved. Only seven cases have been reported in the literature. Ours is the first case involving the tibia. CASE REPORT We report a rare case of malakoplakia of ...
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